Literature summary extracted from

Leblond, F.; Seidah, N.G.; Precourt, L.P.; Delvin, E.; Dominguez, M.; Levy, E.
Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells (2009), Am. J. Physiol. Gastrointest. Liver Physiol., 296, G805-G815.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.61	Homo sapiens	Q8NBP7	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.61	additional information	Caco-2/15 cell	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.61	low-density lipoprotein receptor	PCSK9 posttranslationally promotes the degradation of the low-density lipoprotein receptor	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.61	PCSK9	-	Homo sapiens
3.4.21.61	proprotein convertase subtilisin/kexin type 9	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
3.4.21.61	Homo sapiens	cholesterol (0.1 mM) solubilized in albumin or micelles significantly downregulates PCSK9 gene (30%) and protein expression (50%) in Caco-2/15 cells. Cells treated with 25-hydroxycholesterol (0.05 mM) also display significant reduction in PCSK9 gene (37%) and protein (75%) expression. Addition of bile acids taurocholate and deoxycholate to the apical culture medium lowers PCSK9 gene expression (25%) and raises PCSK9 protein expression (30%), respectively, probably via the modulation of farnesoid X receptor	down
3.4.21.61	Homo sapiens	amounts of PCSK9 mRNA and protein in Caco-2/15 cells are associated to the regulation of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein-2 that can transcriptionally activate PCSK9 via sterol-regulatory elements located in its proximal promoter region. Depletion of cholesterol content by hydroxypropyl-beta-cyclodextrin upregulates PCSK9 transcripts (20%) and protein mass (540%), in parallel with sterol regulatory element binding protein-2 protein levels	up

General Information

EC Number	General Information	Comment	Organism
3.4.21.61	physiological function	PCSK9 plays a role in the small intestine	Homo sapiens

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Release 2023.1 (January 2023)